The somatostatin receptor 2 antagonist 64Cu-NODAGA-JR11 outperforms 64Cu-DOTA-TATE in a mouse xenograft model
Fig 5
Externalization kinetics of 64Cu-DOTA-TATE in HEK-hsst2 cells.
HEK-hsst2 cells were incubated with 64Cu-DOTA-TATE for 2 hours at +37°C. The receptor-bound ligands were removed by washing with glycine buffer, pH 2.8. Cells were then incubated by adding fresh medium and the amount of externalized and internalized (retained) radioactivity in the cells was measured after 10, 20, 30, 60, and 120 minutes.