Scaffold hopping from (5-hydroxymethyl) isophthalates to multisubstituted pyrimidines diminishes binding affinity to the C1 domain of protein kinase C
Fig 1
Comparison of the HMI scaffold (left) with the symmetrical 2,4,6-trisubstituted pyrimidine (center) and the asymmetrical 2,4,5,6-tetrasubstituted pyrimidine (right) scaffolds. Common moieties are color-coded: H-bond donor/acceptor hydroxy groups are shown in blue, carbonyl H-bond acceptor oxygens in red and hydrophobic substituents R in green.