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Fasudil improves endothelial dysfunction in rats exposed to chronic intermittent hypoxia through RhoA/ROCK/NFATc3 pathway

Fig 5

Levels ET-1 in the serum and aorta when subjected to CIH.

(A) ET-1 content was measured in serum from the Normoxia, CIH and CIH+Fa groups by radioimmunoassay. (B) ET-1 protein levels were measured in aortas isolated from the Normoxia, CIH and CIH + Fa groups by western blot. The results were expressed as the mean ± SE. *p < 0.05, CIH group vs Normoxia group; # p < 0.05, CIH + Fa group vs CIH group (n = 6 for each group).

Fig 5

doi: https://doi.org/10.1371/journal.pone.0195604.g005