Development and validation of a physiology-based model for the prediction of pharmacokinetics/toxicokinetics in rabbits
Fig 5
Local sensitivity analysis showing the ten most sensitive parameters for i.v. and p.o. (PO) administration regarding the change in AUC and Cmax.
ESAEF stands for Effective Surface Area Enhancement Factor. Upper panel shows sensitivity indices values for AUC variation, and the lower panel sensitivity indices values for Cmax variation.