Assessment of MMP-2/-9 expression by fluorescence endoscopy for evaluation of anastomotic healing in a murine model of anastomotic leakage
Fig 4
Specificity experiment to rule out unspecific binding of the tracer at the site of inflammation.
Left panel: Ex vivo detection of the specific (Cy5.5-AF443) and unspecific (Cy3.5-Glycine) tracers using the IVIS spectrum system within the same mice was used for investigation of specificity. Right panel: Comparison on the different time points shows significantly higher signal to noise ratio (SNR) with the specific tracer compared to the non specific fluorophore (p = 0.0019).