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Mycophenolic acid induces senescence of vascular precursor cells

Fig 1

ECFC identification criteria.

ECFC display clonogenic potential (A), cobblestone morphology [scale bar = 100 μm] (B) and have ability to form cord-like structures in 2D Matrigel dishes (C) and vessel-like structures in 3D collagen matrix (D) in vitro. Abbreviations: ECFC = endothelial colony forming cell, MPA = mycophenolic acid, LPP-ECFC = low proliferative potential—endothelial colony forming cells, HPP-ECFC = high proliferative potential-endothelial colony forming cells.

Fig 1

doi: https://doi.org/10.1371/journal.pone.0193749.g001