In silico and in vitro studies of the reduction of unsaturated α,β bonds of trans-2-hexenedioic acid and 6-amino-trans-2-hexenoic acid – Important steps towards biobased production of adipic acid
Fig 10
Identification of ring closure product of 6-amino-trans-2-hexenoic acid.
NMR spectra of A) 6-amino-trans-2-hexenoic acid at 25°C before heating, B) 6-amino-trans-2-hexenoic acid after being heated at 90°C for 6 h, where additional peaks can be seen, indicated by asterisks. C) NMR spectrum of 2-pyrrolidineacetic acid. D) Proposed 2-pyrrolidineacetic acid formation mechanism by intra-molecular cyclization.