DJ-1 based peptide, ND-13, promote functional recovery in mouse model of focal ischemic injury
Fig 3
DJ-1 KO mice show higher sensitivity and less spontaneous recovery after ischemic injury compared to C57BL/6 mice.
DJ-1 KO mice show slower spontaneous recovery compared to C57BL/6 mice and are more sensitive to ischemic insult. DJ-1 KO mice spent significantly more time crossing the beam in the elevated bridge test (A, p<0.05) than wild type mice. DJ-1 KO mice show only 5% recovery from day 2 to days 7 after injury, compared to C57BL/6 mice that improved by 20% over the same period of time. Improvement was also noted in cylinder test 7 days after injury (B). (Data is shown as mean ± SEM).