Fosmetpantotenate (RE-024), a phosphopantothenate replacement therapy for pantothenate kinase-associated neurodegeneration: Mechanism of action and efficacy in nonclinical models
Table 6
Estimated blood and dialysate pharmacokinetics of fosmetpantotenate, PPA, and PA in male mice after a single dose of fosmetpantotenate at 700 mg/kg PO or 125 μg intrastriatally and in monkeys following a single PO dose of fosmetpantotenate at 100 or 300 mg/kga.