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Fosmetpantotenate (RE-024), a phosphopantothenate replacement therapy for pantothenate kinase-associated neurodegeneration: Mechanism of action and efficacy in nonclinical models

Fig 3

Intracellular CoA concentrations in shRNA PanK2 knockdown human neuroblastoma cells following incubations with fosmetpantotenate.

Experiment in triplicate. One-way ANOVA with Dunnett’s post-hoc analysis; *** p ≤0.001 **** p≤0.0001. NS: not significant.

Fig 3

doi: https://doi.org/10.1371/journal.pone.0192028.g003