Fosmetpantotenate (RE-024), a phosphopantothenate replacement therapy for pantothenate kinase-associated neurodegeneration: Mechanism of action and efficacy in nonclinical models
Fig 2
Mechanism of action postulated for fosmetpantotenate.
DPCK: dephospho-CoA kinase; PPAT: 4’-phosphopantetheine adenylyltransferase; PPCDC: (R)-4’-phospho-N-pantothenoylcysteine decarboxylase; PPCS: 4’-phosphopantothenoylcysteine synthetase.