Testosterone-induced benign prostatic hyperplasia rat and dog as facile models to assess drugs targeting lower urinary tract symptoms
Fig 4
Voiding behavior in testosterone-induced BPH dogs.
Prostatic dimensions were obtained with ultrasonic diagnosis instrument before castration (pre-BPH) and 8 weeks after testosterone propionate administration (BPH). (A-D) Representative ultrasound images of the prostates of a pre-BPH dog (A and B) and a testosterone-induced BPH dog (C and D). Line 1, line 2 and line 3 represented the prostate length, width and thickness, respectively. Dog prostate volume = length × width × thickness. The prostate volume (E) and prostate volume to body weight ratio (F) of pre-BPH and testosterone-induced BPH dogs. H&E stains of prostate in pre-BPH and BPH dogs (G and H). (I) Micturition frequency, (J) mean voided volume and (K) total voided volume in the first 2 hours after water load were measured at 8 weeks after the induction of BPH. *P < 0.05 and ***P < 0.001 versus pre-BPH control (Student t test). Scale bar, 50μm.