Testosterone-induced benign prostatic hyperplasia rat and dog as facile models to assess drugs targeting lower urinary tract symptoms
Fig 3
Effects of silodosin on the micturition parameters in BOO rats.
BOO rat model was established by partial ligature of the proximal urethra. Voiding behavior was studied after 4 weeks of recovery. Twenty minutes after oral administration of silodosin, distilled water (30 ml/kg) were given orally. (A) Micturition frequency, (B) mean voided volume and (C) total voided volume were measured for the first 2 hours after water load. ##P < 0.01 versus sham control (Student t test). *P < 0.05, **P < 0.01 and ***P < 0.001 versus vehicle control (One-way ANOVA test).