Testosterone-induced benign prostatic hyperplasia rat and dog as facile models to assess drugs targeting lower urinary tract symptoms
Fig 1
Voiding behavior in testosterone-induced BPH rats.
The rat BPH model was generated by testosterone injections for 4 weeks after castration. Sham: sham operated + olive oil injection; BPH: castration + testosterone propionate injection (dissolved in olive oil, 25 mg/kg, once daily). (A) Prostate (containing the ventral, lateral and dorsal lobes) weight and (B) prostate weight to body weight ratios (PW/BW) of sham and BPH rats. H&E stains of dorsal lobe (C and D) and ventral lobe in shame rats and BPH rats (E and F). (G) Micturition frequency, (H) mean voided volume and (I) total voided volume were measured in sham and BPH rats in the first 2 hours after water load (30 ml/kg). **P < 0.01, ***P < 0.001 versus sham control (Student t test). Scale bar, 50μm.