Lapachol inhibits glycolysis in cancer cells by targeting pyruvate kinase M2
Fig 2
Lapachol inhibits glycolysis in melanoma cells.
(A) Extracellular acidification rate (ECAR) under basal (glycolysis) and maximal (glycolytic capacity) after the addition of oligomycin A (10 μM) were plotted for MEL526 and MEL 103 cell lines after the treatment of cell lines with lapachol at concentrations 0 μM, 5 μM, 10 μM, 20 μM and 40 μM overnight. Each value represents mean ECAR value ± se from five replicates (B) Oxygen consumption rate (OCR) under basal and maximal (after the addition of FCCP 30 μM) were plotted for MEL 526 and MEL103 cell lines after the treatment of cell lines with lapachol at concentrations 0 μM, 5 μM, 10 μM, 20 μM and 40 μM overnight.