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Docking and quantitative structure–activity relationship of bi-cyclic heteroaromatic pyridazinone and pyrazolone derivatives as phosphodiesterase 3A (PDE3A) inhibitors

Fig 4

Template-based alignments of PDE3A inhibitors.

(a) Sets 2–4, (b) sets 1 and 5 in alignment PPA, and (c) sets 1 and 5 in PA. Pyrazolopyridine and pyridazinone/pyrazolone moieties are highlighted in orange and magenta, respectively.

Fig 4

doi: https://doi.org/10.1371/journal.pone.0189213.g004