The acute glucose lowering effect of specific GPR120 activation in mice is mainly driven by glucagon-like peptide 1
Fig 7
Exendin 9–39 blocked the AZ13581837 induced potentiation of insulin secretion in lean mice.
Insulin levels following intravenous glucose challenge (A) and corresponding blood glucose (C), after administration of AZ13581837, exendin 9–39 or a co-administration of both, with corresponding calculations of AIR (B) and glucose elimination (D). The IVGTT data are from two independent experiments with n = 10 mice per group. Data are presented as mean ± SEM.***p<0.001 and *p<0.05 versus vehicle control.