The acute glucose lowering effect of specific GPR120 activation in mice is mainly driven by glucagon-like peptide 1
Fig 6
AZ13581837 had no effect on insulin secretion in GPR120 null mice.
Insulin (A) and blood glucose (C) levels following an intravenous glucose challenge after administration of AZ13581837 in female, lean wt or GPR120 null mice and corresponding AIR (B) and glucose elimination (D). The results are from one experiment with n = 4 per group. Data are presented as mean ± SEM.**p<0.01, *p<0.05.