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Wnt co-receptors Lrp5 and Lrp6 differentially mediate Wnt3a signaling in osteoblasts

Fig 5

Wnt3a regulated genes in Lrp5^KO osteoblasts.

A) Venn diagram showing overlap between genes up-regulated in Wnt3a treated Lrp5^KO OBs (Lrp5^KO+Wnt3a) compared to sham treated WT OBs (WT) and sham treated Lrp5^KO OBs (Lrp5^KO). B) Venn diagram showing overlap between genes down-regulated in Wnt3a treated Lrp5^KO OBs (Lrp5^KO+Wnt3a) compared to sham treated WT OBs (WT) and sham treated Lrp5^KO OBs (Lrp5^KO). C) Heatmap showing genes up- or down-regulated by Wnt3a in both WT OBs (WT +Wnt3a) and Lrp5^KO OBs (Lrp5^KO+Wnt3a) compared to WT (WT) controls. D) Heatmap showing genes up- or down-regulated by Wnt3a in WT OBs (WT +Wnt3a) but, not in Lrp5^KO OBs (Lrp5^KO+Wnt3a) compared to WT (WT) controls. These genes either had a fold change < 1.5 or FDR corrected p-value > 0.05.

doi: https://doi.org/10.1371/journal.pone.0188264.g005