Flavin-containing monooxygenase 3 (FMO3) role in busulphan metabolic pathway
Fig 4
The effect of FMO3 inhibition on concentration-time curve of tetrahydrothiophene (THT) in mice.
To study the effect of FMO3 inhibition on THT kinetics, animals were divided into two groups. All experiments were run with 3 mice per time point in each group. Animals were euthanized and blood samples collected at different time points. Group 1. A single dose of THT (8.8mg/kg) was administered i.p. to mice. Group 2. THT (8.8mg/kg) was administered 24h after pretreatment with the FMO3-inhibitor phenylthiourea (PTU, 3mg/kg; i.p.) for 3 days. Pretreatment with PTU significantly (P<0.05) increased plasma levels of THT (Δ, dashed line) compared to that observed when THT was administered alone (□, solid line).