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Mathematical model of early Reelin-induced Src family kinase-mediated signaling

Fig 7

Model validation.

(A) Prediction bands for an EC50 concentration of Reelin for both monomer (red dashed lines) and complex (black solid lines) models. Data is shown as open circles with errors. The shaded areas correspond to the standard deviation of the model predictions. (B) Model trajectories for Reelin stimulus after SFK inhibition, if SFK-dependent trans-phosphorylation between Dab1 proteins in the cluster is prohibited.

Fig 7

doi: https://doi.org/10.1371/journal.pone.0186927.g007