Mathematical model of early Reelin-induced Src family kinase-mediated signaling
Fig 2
Time course of Reelin stimulation in neurons.
Activation and degradation of core components of lipoprotein receptor-dependent Reelin signaling were measured by use of quantitative western blotting. Representative blots of tyrosine-phosphorylation of the neuronal adaptor protein Dab1, total Dab1, total VLDLR and total ApoER2, activation of Src family kinases as well as activation of the PI3 kinase targeting molecule Akt/PKB in primary cortical neurons prepared from E15.5 mice are shown for (A) 0–30 min and (B) 0–240 min of Reelin stimulation.