Pneumococcal responses are similar in Papua New Guinean children aged 3-5 years vaccinated in infancy with pneumococcal polysaccharide vaccine with or without prior pneumococcal conjugate vaccine, or without pneumococcal vaccination
Fig 5
Pneumococcal serotype-specific memory B-cell responses.
Serotype-specific Antibody Forming Cells (AFCs) per 1x106 cultured PBMCs were measured at 10 months of age (1 month after PPV23 vaccination) and pre-challenge at 3–5 years of age in a subset of children vaccinated with PCV7 and PPV23 (white bars) or PPV23-only (grey bars), and pre-challenge at 3–5 years of age in a subset of children not vaccinated with any pneumococcal vaccines (striped pattern). Serotypes with an asterisk (*) are included in PPV23 only, while other serotypes are included in both PCV7 and PPV23. Data are presented as means and 95% confidence intervals. No significant differences were found between groups at 10 months or 3–5 years of age (tested using Mann-Whitney U test). Differences in responses at 10 months versus 3–5 years of age within a group were tested using Wilcoxon Signed Rank Test, and where significant differences were found this has been indicated in the graph.