Idiopathic hypereosinophilia is clonal disorder? Clonality identified by targeted sequencing
Fig 5
An illustration indicating action levels of discovered genes in the present study in relation to eosinophil production and Pathway Studio network analysis.
Networks were created based on at least one published reference regarding candidate genes and the known 14 genes related to eosinophil production. (A) Genes marked with blue letter are well-known genes for which mechanisms are proven in eosinophil production. (B) Genes exerting on eosinophil lineage commitment at hematopoietic stem cell level. (C) Genes exerting at eosinophil lineage commitment and prolongation of eosinophil survival. (D) Eosinophil recruitment into tissue. (E) Genes interacting with IL-5, pivotal to eosinophil production and differentiation. GATA1 and CEBPA were excluded from the network because they are involved in both eosinophil lineage commitment and the candidate gene set.