In vitro and in vivo effects of 2,4 diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS: Context-specific modulation of SMN transcript levels
Fig 13
Volcano plots of differentially regulated genes detected by RNA-Seq analysis of spinal cord tissues from 2B/- SMA mice or 2B/+ healthy littermates treated with RG3039 or vehicle.
The table (E.) summarizes the number of significantly (P<0.05) differentially-regulated genes irrespective of the fold change for the various comparisons and as a percentage of the total numbers of genes detectable. Upregulated is defined such that the first condition in the comparison caused upregulation relative to the second e.g. 3,041 genes were upregulated by RG3039 treatment of SMA mice in comparison to vehicle-treated SMA mice. For all the comparisons the total number of detectable genes was between 20,514 and 20,517.