In vitro and in vivo effects of 2,4 diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS: Context-specific modulation of SMN transcript levels
Fig 12
Smn protein levels in spinal cord and muscle tissue from 2B/- SMA mice or 2B/+ healthy littermates treated with either vehicle, RG3039, or PF-06738066.
Tissues were collected as described in Materials and Methods. Data is expressed as mean s.e.m. and statistical significance was evaluated using One-way ANOVA and Dunnett's multiple comparisons test. Tukey post-hoc tests were utilized to determine significance among the groups. P<0.05 (*), P<0.01(**), P<0.001(***), P<0.0001(****).