In vitro and in vivo effects of 2,4 diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS: Context-specific modulation of SMN transcript levels
Fig 10
Effect of DAQ-DcpSi on the performance of 2B/- SMA mice in a combined 55° negative geotaxis/ climb test.
Data presented represent combined sexes for RG3039 (n = 20); vehicle (n = 21), PF-06738066 (n = 21) and vehicle treated healthy 2B/+ littermates (n = 24). The percent of mice able to pass the 55° negative geotaxis and climb tests simultaneously is shown. At P16, while a predominant number of vehicle treated SMA were alive, PF-06738066 or RG3039 showed improvement over vehicle SMA mice that did not reach statistical significance (Fisher’s exact test, P-value = 0.0708; 43% power to detect a benefit amongst SMA groups).