In vitro and in vivo effects of 2,4 diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS: Context-specific modulation of SMN transcript levels
Fig 9
Effect of DAQ-DcpSi on survival and body weight of 2B/- SMA mice.
RG3039 (6 mg/kg) or PF-06738066 (10mg/kg) were dosed b.i.d. via intraperitoneal injection using a dosing volume of 2.5 μl/g and controls received an equal volume of vehicle. Healthy 2B/+ littermate controls dosed with vehicle were included for comparison. Data presented represent combined sexes for RG3039 (n = 20); vehicle (n = 21), PF-06738066 (n = 21) and vehicle treated healthy 2B/+ littermates (n = 24). All data shown as mean ± s.e.m. and where not shown error bars are within the size of the symbols. RG3039 and PF-06738066 had a significant beneficial effect on survival of SMA mice compared to vehicle SMA mice (P < 0.0001 by either Mantel-Cox or Gehan-Breslow-Wilcoxon tests). RG3039 had a slightly greater effect on survival than PF-06738066 (P < 0.05 by either test).