Receptor for advanced glycation end-products and World Trade Center particulate induced lung function loss: A case-cohort study and murine model of acute particulate exposure
Fig 3
PM exposure affects small airways to a greater degree in WT compared to Ager-/- mice.
(A) WT-PM mice had significantly elevated tissue resistance at 1Hz p<0.001 (*). Ager-/—PM had significantly decreased tissue resistance at 1Hz (†) compared the Ager-/—PBS. (B) WT-PM, but not Ager-/—PM mice had significantly (*) higher tissue damping compared to controls. N ≥5 mice per group. WT-PBS = 7, WT-PM = 15, Ager-/—PBS = 8, and Ager-/—PM = 7 mice were analyzed.