Receptor for advanced glycation end-products and World Trade Center particulate induced lung function loss: A case-cohort study and murine model of acute particulate exposure
Fig 2
Ager -/- mice are protected from loss of lung function 24 hours after WTC-PM exposure.
24 Hours after a single exposure to WTC-PM, WT mice show significant differences in (A) FEV0.2 (B) compliance and (C) resistance compared to PBS controls. These parameters did not differ between Ager-/- mice exposed to PM and their PBS controls. (D) Airway Hyperreactivity (PC200): WT-PM mice exhibited hyperreactivity, whereas Ager-/—PM did not. A total of WT-PBS = 7, WT-PM = 15, Ager-/—PBS = 8, and Ager -/—PM = 7 mice were analyzed. WT-PBS = 2, WT-PM = 3 and Ager-/—PM = 2 were excluded from FEV0.2 analyses as they did not meet standards outlined in the methods. Additionally, WT-PBS = 1 was excluded from methacholine analysis due to a dosing error.