Docking-based modeling of protein-protein interfaces for extensive structural and functional characterization of missense mutations
Fig 5
LHON interaction network with disease-related nsSNPs located at modeled protein-protein interfaces.
Proteins associated with LHON pathology (circles) and their modeled interactions (edges) with other proteins of the network (squares), showing the disease nsSNPs (for LHON and other pathologies) that are located at the modelled protein-protein interfaces. The homology-modeled structures for selected proteins are shown in ribbon, with disease nsSNPs in CPK representation, and all residues colored according to their NIP value (in red NIP > 0.2; in blue NIP < 0.0).