Targeting lysyl oxidase reduces peritoneal fibrosis
Fig 5
Progesterone and dexamethasone reduce NT-induced fibrotic gene expression in abdominal wall PMC.
Effect of i.p treatment with carbon nanotube (NT, 25 μg) followed by daily injection for 7 days with PBS (vehicle), progesterone (Prog, 10 μg/kg), dexamethasone (Dex, 1 μg/kg) or Prog+Dex on lox (A), bone morphogenetic protein 1 (Bmp1) (B), Col1a1 (C) and Col3a1 (D) mRNA expression by abdominal wall peritoneal mesothelial cells in vivo. mRNA expression is shown relative to control day 0 untreated animals (PBS) and is the mean ± SEM of 8–10 animals per treatment. *, p<0.05; **, p<0.01; ***, p<0.001. One-way ANOVA with Tukey’s multiple comparison post-hoc testing.