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Imidazoquinoxaline anticancer derivatives and imiquimod interact with tubulin: Characterization of molecular microtubule inhibiting mechanisms in correlation with cytotoxicity

Fig 4

EAPB0203, EAPB0503 and imiquimod bind tubulin.

Binding levels of EAPB0203, EAPB0503 and imiquimod were determined by surface plasmon resonance on immobilized tubulin at different concentrations (n = 4, except for colchicine n = 1).

Fig 4

doi: https://doi.org/10.1371/journal.pone.0182022.g004