Spike patterning in oxytocin neurons: Capturing physiological behaviour with Hodgkin-Huxley and integrate-and-fire models
Fig 5
Fitting the HH model to ISI distributions.
(A) shows examples of the HH model spiking activity used to generate the ISI distributions. (B) shows in maroon the ISI distributions generated by the original HH model, at firing rates of 2.3 spikes/s (left) and 9 spikes/s (right), compared with reference data (blue). These were achieved with EPSC rates (Repsc) of 505 Hz and 769 Hz. In both the proportion of short ISIs is larger than in the reference data (in blue), and the mode is earlier. (C) shows the ISI distributions from the HH model with τpd, the deactivation time constant of IBK, increased from 1.22 to 10 ms. EPSC rates (Repsc) were slightly increased, to 506 Hz and 774 Hz, to reacquire the firing rates of 2.3 and 9 spikes/s. In the adjusted model, the ISI distributions fit the reference distributions well at both firing rates.