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Discovery of novel brain permeable and G protein-biased beta-1 adrenergic receptor partial agonists for the treatment of neurocognitive disorders

Fig 7

Effects of structural modifications of the phenolic OH moiety of xamoterol on the cAMP pathway mediated by ADRB1.

clogP^a, Calculated with ChemDraw Pro Version 16.0 (PerkinElmer Health Sciences, CT; EC₅₀ (nM)^b, Geometrical mean of EC50 values from at least two independent experiments; % Iso max^c, Percent efficacy compared to the maximum response achieved with isoproterenol; ~^d, Could not be determined.

doi: https://doi.org/10.1371/journal.pone.0180319.g007