Morphological analysis of human umbilical vein endothelial cells co-cultured with ovarian cancer cells in 3D: An oncogenic angiogenesis assay
Fig 2
Morphology characterisation of different in vitro models used in the study.
(A) Representative pictures of (A) HUVECs in mono-culture, (B) OVCAR8 in mono-culture, (C) 3D co-culture of both cell types in the Matrigel sandwich, and (D) on-top co-culture of both cell types on top of the Matrigel at day 1 (24 hours after seeding on day 0), day 3, day 5, day 7 and day 10. It is noticeable that the tubule structures of HUVECs mono-culture started to degrade at day 3.