Lipo-PGE1 suppresses collagen production in human dermal fibroblasts via the ERK/Ets-1 signaling pathway
Fig 5
Scheme representing the suppression of collagen production in HDFs after Lipo-PGE1 treatment.
Lipo-PGE1 strongly inhibits collagen synthesis in HDFs. Furthermore, an ERK- and Ets-1-dependent pathway is involved in Lipo-PGE1-inhibited collagen production. Lipo-PGE1 can be modulated to down-regulate collagen synthesis in human HDFs and may provide a therapeutic approach to inhibit fibrosis and its roles in the pathogenesis of skin disorders.