Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes
Fig 3
Cell-lines with MSI are specifically sensitive to chemical inhibition of FEN1 by compounds 1 and 3.
A. Box and whisker diagram to show the variation in GI50 values for cell-lines subject to treatment with 1 and 3. B. Correlation between the sensitivity of cell-lines to 1 and 3. C-H. The influence of MSI on sensitivity to DNA repair inhibitors. ns = not significant * p < 0.05. ** p < 0.005.