Evaluation of somatostatin and nucleolin receptors for therapeutic delivery in non-small cell lung cancer stem cells applying the somatostatin-analog DOTATATE and the nucleolin-targeting aptamer AS1411
Fig 4
Uptake of 57Co labeled DOTATATE in the NSCLC cell line H1299.
The subcellular distribution of 57Co-DOTA-AS1411 in H1299 adherent cells (A) and in H1299 spheres (B) as a function of increasing incubation time (1–23 h). In each case a blocking experiment was performed with 1000-fold excess AS1411 (23h block). Mean uptake (mBq/cell) is expressed as mean ± SEM from triplicate experiments.