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Gene and metabolite time-course response to cigarette smoking in mouse lung and plasma

Fig 5

Genes showing a previously unsuspected significant time trend with CS exposure.

(A) Fam162b shows a significant downward trend for linear time and significant effect of group. (B) Grm4 shows significant upward trend for linear time and significant effect of group. (C) Lox was bi-directionally regulated in individual time point analysis. (D) Slc22a12 displayed significant linear time by treatment interaction, with no change in expression in the AC group.

Fig 5

doi: https://doi.org/10.1371/journal.pone.0178281.g005