Voxelwise distribution of acute ischemic stroke lesions in patients with newly diagnosed atrial fibrillation: Trigger of arrhythmia or only target of embolism?
Fig 5
Differences of infarct locations: New AF versus no AF.
(A): New AF was, compared to patients without AF, associated with ischemic lesions in a) the right (peri-) insular cortex and the caput of the right caudate nucleus and b) in the left PCA territory. Patients without AF had significantly more often strokes in the left parietal lobe than patients with new AF. (Red-to-yellow: areas significantly more often associated with strokes in patients with new AF vs. without AF, blue-to-lightblue: vice versa and green: overlap projections; thresholded at FDR-corrected q = 0.01; age and gender were included as covariates of no interest, with infarct volume unaccounted for in this analysis). (B): Including infarct volume into the analysis revealed that no specific brain region was associated with significantly more stroke lesions in patients with new AF compared to patients without AF. Vice versa, patients without AF still had more often left parietal involvement compared to patients with new AF. (Red-to-yellow: areas significantly more often associated with strokes in patients with new AF vs. without AF [none], blue-to-lightblue: vice versa; FDR-corrected q = 0.01; with removal of the confounding effect of cubic root infarct volume normalized for brain size, age and gender).