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Increased anxiety-like behavior is associated with the metabolic syndrome in non-stressed rats

Fig 5

Effect of a 24 week high-sucrose diet on anxiety-like behavior as measured in the open-field test.

The high-sucrose diet group exhibited a reduction in the time spent in the central squares (A) and an enhancement in freezing behavior (B) as compared with the control group. Moreover, a decrease of the total distance traveled by the rats within the open-field was observed in the group submitted to the high-sucrose diet (C). Bars represent means ± SEM. Mann-Whitney Test was conducted, **p<0.001. Control group n = 27, high-sucrose diet group n = 24.

Fig 5

doi: https://doi.org/10.1371/journal.pone.0176554.g005