Automated assessment of bone changes in cross-sectional micro-CT studies of murine experimental osteoarthritis
Fig 5
Microstructural assessment of subchondral bone compartments.
Subchondral bone plate (A) volume and (B) thickness, and trabecular (C) total volume and (D) BV/TV, (E) subchondral bone plate BMD, and (F) trabecular BMD within the automated volumes-of-interest of medial and lateral aspects of the plateau for DMM-operated and contralateral tibiae (n = 6, * denotes comparisons between measurements in the non-operated baseline (time 0) with subsequent time points post-surgery, while # denotes comparisons between DMM-operated vs. contralateral aspects of tibial plateau at the same time point, obtained by two-way ANOVA followed by post hoc multiple comparison tests using Bonferroni correction). *P<0.05, **P<0.01, ***P<0.001 and ****P<0.0001 (both * and # symbols denote the same levels of significance).