Optimizing ultrasound molecular imaging of secreted frizzled related protein 2 expression in angiosarcoma
Fig 8
Verifying performance of optimized molecular imaging reagents, and protocol in vivo.
Non-identical superscripts indicate a statistically significant difference in means. Both IgY-targeted (a, p = 0.03), and SFRP2-targeted (c, p < 0.001) contrast produced significantly higher video pixel intensities in tumor ROI compared to peri-tumoral regions (b). SFRP-2 targeted contrast (c, p < 0.001) produced significantly higher signal intensity in tumor ROI than the control IgY-targeted contrast (a). Average video pixel intensities were corrected for free flowing contrast by subtracting the post-destruction VI from the pre-destruction VI as shown in Fig 2B for the ‘image—destroy—image’ method. N = 10 animals.