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Insight into the mechanism of action of temporin-SHa, a new broad-spectrum antiparasitic and antibacterial agent

Fig 1

Schiffer-Edmundson helical wheel representation of temporin-SHa and its analogs.

SHa, temporin-SHa; [K³]SHa, [K³]temporin-SHa; [A^2,6,9]SHa, [A^2,6,9]temporin-SHa; [A^2,6,9, K³]SHa, [A^2,6,9, K³]temporin-SHa. Apolar residues are represented in black and polar/basic residues in gray/white. Amino acid modifications are in bold. An amphipathic character, with two well-separated polar and apolar faces, is observed. Adapted from Heliquest.

doi: https://doi.org/10.1371/journal.pone.0174024.g001