Chronic activation of PPARα with fenofibrate reduces autophagic proteins in the liver of mice independent of FGF21
Fig 2
Effects of FB on hepatic autophagic proteins in PPARα+/+ and PARα-/- mice.
Experiments were conducted as described in Fig 1. (A) Representative of images and (B) quantification of the Western blots for key autophagic proteins. Atg3 (autophagy-related gene protein 3), Atg4B (autophagy-related gene protein 4B), Atg5 (autophagy-related gene protein 5), Atg7 (autophagy-related gene protein 7), LC3 (microtubule-associated protein light chain 3) and p62 (polyubiquitin-binding protein p62). * p<0.05, ** p<0.01 vs control (-FB); † p<0.05, †† p<0.01 vs untreated PPARα+/+ mice; n.s. not statistically significant. n = 5–6/group.