The renal phenotype of allopurinol-treated HPRT-deficient mouse
Fig 4
Transmission electron microscopy.
Tubules from allopurinol-treated HPRT-/- animals appear altered at the subcellular level, showing mitochondrial swelling (yellow arrows, a, b), numerous lysosomes (red arrow, a), shrinking of the tubular basement membrane (blue arrow, b), and loss of the brush border (white arrow, b). Scale bar = 2 μm.