The Effect of Tacrolimus and Mycophenolic Acid on CD14+ Monocyte Activation and Function
Fig 1
Simplified overview of intracellular signaling pathways involved in monocyte activation.
After toll like receptor (TLR) or FC-γ receptor activation the MAPK, Akt and NFAT pathways are activated upstream. The phosphorylation of the intracellular signaling proteins leads to the activation of transcription factors, such as CREB and NF-κB p65, which after activation leads to gene transcription. This process determines the function of monocytes including phenotypic differentiation, cytokine production and phagocytosis.