Mice with an N-Ethyl-N-Nitrosourea (ENU) Induced Tyr209Asn Mutation in Natriuretic Peptide Receptor 3 (NPR3) Provide a Model for Kyphosis Associated with Activation of the MAPK Signaling Pathway
Fig 5
p38 MAPK signaling in vertebral growth plates.
Vertebral sections from 1 day old wild-type (WT) and Kylb/Kylb male mice were stained with antibodies against phosphorylated p38 MAPK and MKK3/MKK6. Vertebrae from Kylb/Kylb mice had increased staining in the resting (RZ), proliferative (PZ) and hypertrophic (HZ) zones, but not in the bone matrix (BM), when compared to vertebrae from WT littermates. Scale bars = 50μm.