Exendin-4 Inhibits Hepatic Lipogenesis by Increasing β-Catenin Signaling
Fig 2
Exendin-4 inhibits palmitic acid-induced hepatic lipogenesis and TG synthesis.
HepG2 cells were treated with palmitic acid (PA; 400 μM) either with or without exendin-4 (Ex-4; 100 nM) for 24 hours. The mRNA expression levels of SREBP-1c, PPARγ, SCD1, FAS, ACC, DGAT1, and DGAT2 were normalized to the level of β-actin. All values are expressed as the mean ± SE (n = 6). * p<0.05, ** p<0.01 compared with control cells; # p<0.05, ## p<0.01 compared with PA-treated cells.